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You wake up in the morning with a throbbing headache, not quite feeling like  P. Diddy.  When coffee and water can’t alleviate the pain caused by last night’s poor decisions, you might reach for some common over-the-counter pain relievers. 

While many people assume that all pain relievers  function in the same way, each respective drug is metabolized differently, providing distinct physiological effects.  

Ibuprofen (Advil), acetaminophen (Tylenol) and aspirin are the most common pain relief medications consumed by the general public.

Advil and aspirin have anti-inflammatory properties, while Tylenol is an anti-pyretic medication (fever reducer).

For a hangover, Advil is the best option for alleviating the pain associated with a headache since it doesn’t have the same effects that Tylenol has on alcohol metabolism in the liver.

Tylenol’s metabolism in the liver affects a specific enzyme working to break down alcohol into non-toxic chemicals, thereby decreasing the rate of alcohol metabolism and prolonging your hangover. 

Tylenol and aspirin can actually multiply the effects of alcohol on the body if taken after drinking.

Alcohol will accumulate in the blood faster, extending its negative effects. 

However, that does not mean Advil is the go-to pill for every problem; Advil and aspirin can both contribute to the formation of stomach ulcers and should be taken in moderate quantities. They should not be taken for stomach pains.

Advil and aspirin’s anti-inflammatory properties interfere with a certain chemical involved in inflammation (prostaglandins) that aid in the repair of damaged stomach tissue by stomach acid.

Upon prostaglandin inhibition, certain components of the immune system are compromised, affecting the repair of the damaged tissue.

As these wounds within the stomach continue to form and worsen, painful ulcers result.

Aspirin has been most commonly used as an anti-coagulant (blood thinner), reducing the risk of heart attacks and high blood pressure. 

For general aches and pains, each is an acceptable medication to be taken at moderate levels.

However, one should consult a physician before taking these drugs on a regular basis.  

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